Enterprising cancer treatment ideas nurtured with pilot funds

pilot-project-collage

Finding new treatment targets for aggressive prostate cancer, lymphoma and leukemia. Visualizing how breast tumors grow resistant to drug therapy. Using mobile phone sensors to track symptoms in patients with pancreatic cancer. These are some of the new pilot projects funded by the OHSU Knight Cancer Institute.

The $50,000 grants help early career and senior investigators generate preliminary data to pursue more expansive funding from external, peer-reviewed sources such as the National Institutes of Health. The awards are made possible by support from philanthropic donors and the Knight Cancer Institute’s NCI Cancer Center Support Grant.

anupriya-agarwalAnupriya Agarwal, Ph.D., Shannon McWeeney, Ph.D., Andrew Adey Ph.D.

Microenvironment-driven inflammatory signals: A role in clonal evolution of pre-leukemia cells in AML
Albert and Elaine Borchard Foundation

Alumkal_Joshi_portrait_smJoshi Alumkal, M.D., Laura Heiser, Ph.D., and Xiangshu Xiao, Ph.D.

Targeting CREB1 in Enzalutamide-Resistant, Lethal Prostate Cancer
Noel and Carolyn Lesley

beattyheadKimberly Beatty, Ph.D., and Jim Korkola, Ph.D.

Imaging drug-resistance mechanisms in HER2-positive breast cancer
The Hillcrest Committee

 


lulu-cambronneLulu Cambronne, Ph.D.

How cancer metabolism banks on mitochondrial NAD+
The Hillcrest Committee

 


Alexey Danilov MD

Alexey Danilov, M.D., Ph.D., and Peter Hurlin, Ph.D.

Targeting c-Myc by selective inhibition of cyclin-dependent kinase-9 (CDK9) in diffuse large B-cell lymphoma
Albert and Elaine Borchard Foundation

 


leonard-jessica_16-canJessica Leonard, M.D.

Identifying novel signaling pathways in Adult ALL
Albert and Elaine Borchard Foundation

 


marks_for_endoDaniel Marks, M.D., Ph.D., and Aaron Grossberg, M.D., Ph.D.

Mobile device-collected actigraphy as a tool for early detection and symptom monitoring in patients with pancreatic cancer
Kemmerer Foundation

 


mccullough-amandaAmanda McCullough, Ph.D., and R. Stephen Lloyd, Ph.D.

DNA Base Excision Repair as a New Target for the Treatment of Acute Myeloid Leukemia
Noel and Carolyn Lesley

 


streeter-4Philip Streeter, Ph.D.

Monitoring Pancreatic Cancer Recurrence by High Resolution Flow Cytometry
The Hillcrest Committee