How to make more cancers vulnerable to immunotherapies
Cancer immunotherapies called checkpoint inhibitors can bring dramatic, life-saving results – but only for a limited fraction of patients. Aiming to help more patients benefit, researchers in...
Category: cancer biology
Overcoming drug resistance to stop a deadly blood cancer
Cancer researchers have discovered a potential way to make targeted therapy drugs more effective and longer lasting for people with acute myeloid leukemia, or AML. The scientists showed how it is...
Discovery sheds light on early-onset colorectal cancer
The rapid rise of colorectal cancer in younger people remains perplexing, but a new study fills in a missing piece of the puzzle. Researchers found that three genes involved in immunity and...
Innovation expands view into workings of single cells
Researchers have devised a way to multiply by more than ten-fold the accessible details of gene activity in individual cells. It’s a big leap in the effort to understand cancer development, brain...
Engineering models of early cancer: Q&A with Carolyn Schutt Ibsen
Carolyn Schutt Ibsen, Ph.D., develops biomaterials that can be controlled remotely and noninvasively using ultrasound. She and her team at OHSU are using these “energy-responsive” materials to...
Perturbed tumors reveal their secrets
A trove of freely accessible cancer data helps researchers find new combination treatments. Targeted cancer therapies work by blocking a specific cancer-driving signal, thus limiting harm to healthy...
Interrogating cancer, one cell at a time: Q&A with Hisham Mohammed
Hisham Mohammed, Ph.D., helped create a way to peer into individual cells and take multiple measures of gene activity and gene regulation at the same time. He’s leading the first research to apply...
Stopping the secretive cells that revive deadly tumors
Cancers are notorious for their ability to rebound uncontrollably after a first round of successful treatment. In a new study, researchers at OHSU have uncovered how a fraction of a tumor’s cells...
New research points to an aggressive form of breast cancer not detected readily by screening
About 20 to 30 percent of women with breast cancer have tumors that are missed by mammogram screening. These interval breast cancers – discovered between routine mammograms – seem to be more...
Understanding the accomplice cells that help drive pancreatic cancer
Mara Sherman’s award-winning research is uncovering the role of non-cancer cells that support tumor growth in pancreatic ductal adenocarcinoma. The pancreatic cancer survival rate, averaging...
How scientists are mapping the cancer ecosystem to find cures
Cancer is more than just tumor cells driven by gene mutations. Cancer is like an ecosystem filled with evolving populations of tumor cells that interact with and enlist support from neighboring...