A new line of attack on deadly prostate cancers
Researchers have uncovered a potential drug target for stopping castration-resistant prostate tumors – the second leading cause of cancer death in the U.S. For decades, drug development for...
Category: cancer biology
Study reveals factors outside of tumors that steer breast cancer aggressiveness
Cancer researchers have identified key factors in the surroundings of tumor cells that it may be possible to target to improve outcomes for patients with HER2-positive breast cancer. Co-principal...
Cancer translated’s top blog posts of 2017
From basic science to survivorship and patient advocacy, the OHSU Knight Cancer Institute’s 'Cancer translated' blog explores new ideas and debates in cancer medicine. We sorted a year’s worth...
Solving the problem of drug-resistant cancer
To discover ways to prevent or delay resistance to cancer therapies, a new NCI-funded center at OHSU is exploring how acute myeloid leukemia cells evolve and adapt. The first successful targeted...
Check out the Knight Cancer pilot project award winners
Preventing skin cancer with a DNA-repair enzyme. Understanding how microRNAs modify cancer immunity. Using zebrafish embryos to rapidly assess toxicity of anticancer drug combinations. These are...
Outsmarting treatment-resistant prostate cancers
Aggressive prostate tumors can rapidly evolve to resist PARP inhibitors, but it may be possible to detect resistance early enough to counteract....
Oregon’s precision medicine pioneer targets earlier cancer detection
OHSU Knight Cancer Institute Director Brian Druker talked with Medscape Editor-in-chief Eric Topol about breaking out of one-size-fits-all thinking in cancer screening and prevention. "We are now in...
A new way to guide cancer immune therapy
Scrutinizing the immune cells infiltrating a tumor may reveal the cancer's vulnerability or resistance to immune-based therapies. Cancer immune therapies have delivered life-saving, long-lasting...
The cancer drug that “changed everything”
Understanding the earliest drivers of cancer formation can lead to less toxic and more effective treatments. It transformed the outlook for people diagnosed with chronic myeloid leukemia. A...
Why breast cancer is more dangerous for new moms
Breast cancers that emerge after a woman gives birth are significantly more deadly. Those diagnosed within five years of childbirth are about three times more likely to spread and give rise to...
Knight Cancer signal achievements of 2016
The staff and faculty of the OHSU Knight Cancer Institute accomplished much together during the past year. Here's a sampling of achievements that reflect the mission of delivering compassionate care...