Unraveling early events in a life-threatening leukemia

Cancer scientists reveal the first direct evidence that leukemia development depends on the order in which mutations occur. Acute myeloid leukemia, or AML, is the most common blood cancer in adults...

Study overturns basic tenet in leukemia biology

Scientists thought they understood the steps leading to acute myeloid leukemia. But one of the basic tenets in that understanding turns out to be unsound, according to researchers at the OHSU Knight...

Studies reveal new ways to fight a deadly leukemia

One study shows how it may be possible to stop acute myeloid leukemia by targeting a hidden population of cells that support the cancer. Another reveals how AML evolves to evade anti-cancer drugs,...

Solving the problem of drug-resistant cancer

To discover ways to prevent or delay resistance to cancer therapies, a new NCI-funded center at OHSU is exploring how acute myeloid leukemia cells evolve and adapt. The first successful targeted...

Zeroing in on drug combos against a formidable form of leukemia

A heat map by Kurtz et al. comparing the sensitivities of leukemia cells to drug combinations. Darker red indicates drug combinations exhibiting higher efficacy than either agent alone. Targeted...

Fighting a formidable leukemia with an expansive clinical trial

The best available treatment for acute myeloid leukemia is a drug combination established more than 30 years ago. And today less than a third of newly diagnosed AML patients survive beyond five...

How a formidable leukemia subverts blood stem cells

New findings open a path for developing desperately needed therapies for the most frequently diagnosed leukemia in adults.   Leukemia paves the way for its deadly advance by manipulating the...