Taking a systems approach to beating cancer

Diversity and adaptability make cancer hard to beat. To survive, tumors find many ways to cooperate with immune and other host cells, and tumors avidly split into sub-populations of cancer cells with...

Detecting tumor responses before they become deadly

Targeted cancer therapies can be stunningly effective at blocking specific, cancer-driving signals. But all too often, tumors develop resistance by switching to alternative signaling pathways to...

Overcoming drug resistance to stop a deadly blood cancer

Cancer researchers have discovered a potential way to make targeted therapy drugs more effective and longer lasting for people with acute myeloid leukemia, or AML. The scientists showed how it is...

First-in-class drug targets resistant ovarian cancer

Cancer researchers have discovered a way to target a pivotal driver of drug resistance in ovarian cancer, one of the top causes of cancer death in women. The experimental compound, called SU056,...

Perturbed tumors reveal their secrets

A trove of freely accessible cancer data helps researchers find new combination treatments. Targeted cancer therapies work by blocking a specific cancer-driving signal, thus limiting harm to healthy...

Stopping the secretive cells that revive deadly tumors

Cancers are notorious for their ability to rebound uncontrollably after a first round of successful treatment. In a new study, researchers at OHSU have uncovered how a fraction of a tumor’s cells...

New path to stop drug-resistant breast cancer

Even when anti-cancer drugs appear to eliminate tumors, a resistant few malignant cells can survive and allow cancers to resume a fatal onslaught. Researchers at OHSU in Portland have revealed a...

Solving the problem of drug-resistant cancer

To discover ways to prevent or delay resistance to cancer therapies, a new NCI-funded center at OHSU is exploring how acute myeloid leukemia cells evolve and adapt. The first successful targeted...