Knight Cancer signal achievements of 2022
People at the Knight Cancer Institute accomplished a lot in 2022. Through innovative, collaborative research and education, the institute delivers cancer prevention, detection, and care — one...
Tag: leukemia
A better roadmap for beating a deadly leukemia
Acute myeloid leukemia, or AML, is the most common acute blood cancer in adults — and one of the most difficult to treat. Scientists at Oregon Health & Science University have discovered a...
Jamming fat metabolism stops blood cancer cells
Targeted cancer therapies work by blocking specific, cancer-driving mutations. But in a new laboratory study, researchers show that cancers driven by several different mutations can all be stopped by...
Beat AML study paves way for precision treatment
Using genetic information to match patients to targeted therapies may improve survival in people with a fast-moving leukemia. Because acute myeloid leukemia is such a fast-moving and deadly cancer,...
Study overturns basic tenet in leukemia biology
Scientists thought they understood the steps leading to acute myeloid leukemia. But one of the basic tenets in that understanding turns out to be unsound, according to researchers at the OHSU Knight...
Dive into the science of precision cancer medicine at Knight School
Targeted therapy drugs have transformed the outlook for people diagnosed with one form of blood cancer, chronic myeloid leukemia. A disease with a three- to five-year life expectancy became, for...
Rapid precision medicine is feasible in fight against a formidable leukemia
The Beat AML clinical trial has matched 250 study participants to targeted treatments for acute myeloid leukemia – with promising early results. Regulators were wary of the complicated study...
Solving the problem of drug-resistant cancer
To discover ways to prevent or delay resistance to cancer therapies, a new NCI-funded center at OHSU is exploring how acute myeloid leukemia cells evolve and adapt. The first successful targeted...
Zeroing in on drug combos against a formidable form of leukemia
A heat map by Kurtz et al. comparing the sensitivities of leukemia cells to drug combinations. Darker red indicates drug combinations exhibiting higher efficacy than either agent alone. Targeted...
The cancer drug that “changed everything”
Understanding the earliest drivers of cancer formation can lead to less toxic and more effective treatments. It transformed the outlook for people diagnosed with chronic myeloid leukemia. A...
How a formidable leukemia subverts blood stem cells
New findings open a path for developing desperately needed therapies for the most frequently diagnosed leukemia in adults. Leukemia paves the way for its deadly advance by manipulating the...