Knight Cancer signal achievements of 2022
People at the Knight Cancer Institute accomplished a lot in 2022. Through innovative, collaborative research and education, the institute delivers cancer prevention, detection, and care — one...
Tag: targeted therapy
The cancer kept coming back
His life was blasted apart by a rare but vicious type of cancer. Could an experimental treatment help? When Derek Fadness woke up, the room was dark and his face was swaddled in bandages. He could...
A better roadmap for beating a deadly leukemia
Acute myeloid leukemia, or AML, is the most common acute blood cancer in adults — and one of the most difficult to treat. Scientists at Oregon Health & Science University have discovered a...
Detecting tumor responses before they become deadly
Targeted cancer therapies can be stunningly effective at blocking specific, cancer-driving signals. But all too often, tumors develop resistance by switching to alternative signaling pathways to...
Jamming fat metabolism stops blood cancer cells
Targeted cancer therapies work by blocking specific, cancer-driving mutations. But in a new laboratory study, researchers show that cancers driven by several different mutations can all be stopped by...
Clinical trial elevates new target for fighting cancers
Researchers have verified a much-needed new target for treating cancers that often become resistant to existing therapies and become deadly. In an early-phase clinical trial, the researchers tested...
Expanding access to experimental cancer treatments in Oregon: Q&A with Shivaani Kummar
This week, the OHSU Knight Cancer Institute opened a new, 13,000-square-foot space devoted to serving patients taking part in early-phase clinical trials. The unit completes the build-out of the...
Overcoming drug resistance to stop a deadly blood cancer
Cancer researchers have discovered a potential way to make targeted therapy drugs more effective and longer lasting for people with acute myeloid leukemia, or AML. The scientists showed how it is...
Targeted ‘radioligand’ improves survival in advanced prostate cancer
Cancer researchers say they have established a new, life-extending treatment option for men with prostate cancer that has spread and become resistant to hormone therapy. The injected treatment...
Unlocking the combination to target evasive kidney cancers
Roughly one in four people with kidney cancer have a type that does not respond to targeted therapy drugs, leaving no proven treatment options for those whose tumors have started to...
Perturbed tumors reveal their secrets
A trove of freely accessible cancer data helps researchers find new combination treatments. Targeted cancer therapies work by blocking a specific cancer-driving signal, thus limiting harm to healthy...