Cracking the code of advanced prostate cancer
Understanding the tumor-specific alterations that are most important for prostate cancer aggressiveness and treatment decision-making will be the focus of a Marquam Hill...
Tag: targeted therapy
A new line of attack on deadly prostate cancers
Researchers have uncovered a potential drug target for stopping castration-resistant prostate tumors – the second leading cause of cancer death in the U.S. For decades, drug development for...
How to retarget cancers that have evaded targeted therapy
Targeted therapy drugs transformed the outlook for people with the rare cancers known as gastrointestinal stromal tumors, enabling some to survive a decade or longer. A fraction of GIST patients,...
Breaking through the limits of cancer medicine
Gordon Mills, M.D., Ph.D., the new director of precision oncology at Oregon Health & Science University, outlines a vision for the field. Photo: Gordon Mills, M.D., Ph.D. (OHSU/Kristyna...
Zeroing in on drug combos against a formidable form of leukemia
A heat map by Kurtz et al. comparing the sensitivities of leukemia cells to drug combinations. Darker red indicates drug combinations exhibiting higher efficacy than either agent alone. Targeted...
Riveting survival stories from the early clinical trials of Gleevec
Medicine had never seen anything like it before, Brian Druker, M.D., recalled. "These are people who’d been told to get their affairs in order. And now their blood counts are normal," the...
The cancer drug that “changed everything”
Understanding the earliest drivers of cancer formation can lead to less toxic and more effective treatments. It transformed the outlook for people diagnosed with chronic myeloid leukemia. A...
When it’s time to stop a lifesaving cancer drug to find out if you are cured
The depth of remission achieved with the targeted therapy imatinib (Gleevec) raises a tough new question for some leukemia patients: is it ever safe to stop taking the breakthrough drug developed at...
Enterprising cancer treatment ideas nurtured with pilot funds
Finding new treatment targets for aggressive prostate cancer, lymphoma and leukemia. Visualizing how breast tumors grow resistant to drug therapy. Using mobile phone sensors to track symptoms...
This is what a ‘game changing’ cancer therapy looks like
Life expectancy in patients with chronic myeloid leukemia has soared to a level almost equal to that of the general population, according to a Swedish study quantifying the life-saving impact of...