DMICE Biomedical Informatics PhD student Joshua Burkhart recently co-authored two journal articles.
The first was an article in Science Advances describing evidence of a novel mechanism for metastasis whereby tumor-infiltrating macrophages fuse with cancer cells to yield binucleated hybrid cells capable of both avoiding immune detection within the vasculature and seeding metastatic sites. The paper was published with members of Dr. Melissa Wong‘s lab and other collaborators.
As a participant of the Sage Bionetworks Respiratory Viral DREAM Challenge, Joshua also worked with DMICE faculty Dr. Shannon McWeeney to develop TSAR, a machine learning strategy to predict human viral response using gene expression data. Following the challenge phase, he participated in working groups to analyze and interpret results along with other challenge participants. Preliminary findings were presented at RECOMB/ISCB Conference on Regulatory & Systems Genomics in November 2017 and the final report was published in Nature Communications.
Joshua noted, “Jeff Bezos gave an interview to Forbes in which he described a situation where he was congratulated for Amazon’s having a profitable quarter and responded by saying ‘Thank you, but that quarter was baked three years ago. I’m working on a quarter that’ll happen in 2021 right now.’ The story brought about a sense of symmetry for me as I’ve recently finished two of my research projects but am already deeply involved in projects that won’t be made public for months or years.”