Transgenic Core and University Shared Resources give four awards to strengthen grant applications

Earlier this year, the Transgenic Mouse Model Core and OHSU University Shared Resource Program held a university-wide call for applications to strengthen the competitiveness of planned grant applications or resubmissions through the generation of novel mouse lines from existing embryonic stem cell lines. The generation of these mouse lines will provide viable proof that such mouse lines can be created, valuable preliminary data, or both. The following four projects were chosen for funding:

Nabil Alkayad, M.D., Ph.D., Department of Anesthesiology
“A conditional mouse line offering cell-type specific analysis of the role of sex hormones on stroke outcome”

Mushui Dai, M.D., Ph.D., Molecular and Medical Genetics
“A novel mouse line to probe how deubiquitination regulates tumorogenesis leading to unique insights into how this impacts potential cancer therapies”

Peter Kurre, M.D., Department of Pediatrics
“The generation of a novel mouse model of Fanconi’s anemia will offer new avenues to discover the cause for stem cell failure and develop novel therapeutics for this genetic disorder”

Zhengfeng Zhou, M.D., Ph.D., Department of Medicine
“A mouse line that carries a human mutation leading to long QT syndrome providing a unique system to develop new targeting strategies for this disease”