Kelsey Martin, M.D. Ph.D.; Benjamin Wolozin, M.D, Ph.D; and J. Paul Taylor, M.D, Ph.D., will present at the 2016 Jungers Center for Neurosciences Research Symposium as part of OHSU Research Week, May 2-6.
2016 Jungers Symposium
“RNA granules: From synaptic plasticity to neurodegeneration”
Monday, May 2
1:30 to 4:30 p.m.
Reception to follow
Kelsey Martin, M.D. Ph.D.
Professor of biological chemistry, psychiatry, and behavioral sciences, executive vice dean, and associate vice chancellor at the David Geffen School of Medicine at UCLA
“Spatial regulatoin of gene expression during synaptic plasticity”
Martin was an English major as an undergraduate at Harvard, then served in the Peace Corps in the Democratic Republic of the Congo before returning to do graduate work at Yale. She was a postdoctoral fellow with Nobel laureate Eric Kandel at Columbia, where she began her work to understand the molecular basis of memories. Her work as a graduate student on ribonucleo-particle transport in influenza virus led her to the question of synapse-specific plasticity in the Kandel lab, then to a career examining neuronal signaling between synapses and gene expression in the nucleus, and on to RNA binding proteins. Martin has been on the faculty of UCLA since 1999 and now serves as the executive vice dean of the David Geffen School of Medicine.
Benjamin Wolozin, M.D., Ph.D.
Professor of pharmacology and neurology, and head of the laboratory of neurodegeneration at Boston University School of Medicine
“Stress ganules and neurodegeneration: A molecular network underlying neurodegeneration”
Wolozin was an undergraduate at Wesleyan before earning his medical and graduate degrees from Albert Einstein College of Medicine. After postdoctoral fellowships at Mt. Sinai and NIMH, he served as a faculty member at the Loyola University Medical Center before moving to Boston University in 2004. Wolozin is interested in how cellular stress response that regulates autophagy, protein translation, and mitochondrial function contributes to Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis. In recent work he has examined the pathophysiology of stress granules (RNA-protein complexes) in Alzheimer’s disease and tauopathies, which he will discuss in his 2016 Jungers Symposium talk.
J. Paul Taylor, M.D., Ph.D.
Chair of cell and molecular biology at St. Jude’s Children’s Research Hospital, and Howard Hughes Medical Institute investigator
“Perturbed RNA granule dynamics in ALS and related diseases”
Taylor did his graduate training at Jefferson Medical College followed by a neurology residency at Penn and a neurogenetics fellowship at NINDS, where he worked with Kenneth Fischbeck and began his continuing interest in toxic, aggregation-prone proteins and neurological disease. He is currently chair of the Cell and Molecular Biology Department at St. Jude Children’s Research Hospital in Memphis, and an HHMI investigator. His work focuses on RNA-protein granules whose functional impairment has been implicated in multiple neurodegenerative diseases including ALS and frontotemporal dementia. In his work, he uses Drosophila to model disease, and is interested in development of small molecule therapeutics. Taylor has examined how disease-causing mutations affect RNA granule formation and the development of fibrillary inclusions of RNA-binding proteins.
Visit the OHSU Research Week website for a complete schedule of events.