Above, Lucia Carbone, Ph.D., is at the Gibbon Conservation Center in Santa Clarita, California, with Lucia, the gibbon named after her.
The July 17, 2018, OHSU Week podcast — Are genomes really like Legos? — features Carbone talking about gibbon conservation, genomic shuffling and how unraveling primate genomes is vitally important as researchers try to understand the genetic factors in human health and disease.
Carbone reported her team’s new findings on the gibbon genome in the July issue of Genome Research.
The white-cheeked gibbon shares 96 percent of its genetic makeup with humans, making this small ape an exceptionally good model for investigating human genomic evolution. It has experienced an unusually high number of chromosomal rearrangements since its divergence from humans.
Four years ago, Carbone led a team that sequenced gibbon DNA for the first time. Now her team has demonstrated that, in spite of extensive genomic shuffling, there is remarkable conservation of the epigenetic landscape in gibbons.